Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a coordinated attack against an hidden munitions depot in Syria operated by the IS group, according to the UK Ministry of Defence.
The facility, identified by reconnaissance, was believed to be storing arms and explosives, the statement said, and was situated in mountainous terrain just above Palmyra in central Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a number of access tunnels leading to the facility... early reports are that the objective was successfully hit," officials stated.
There was no evidence of any civilian impact in the operation late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager tanker plane.
The Islamic State group - referred to as Daesh - enforced militant control over parts of both Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates our UK leadership, and resolve to operate in unison with allied nations, to stamp out any revival of Daesh and their violent and radical beliefs in the region," the British Defence Secretary John Healey stated.
British military aircraft have carried out surveillance missions over Syrian airspace to "forestall any attempted resurgence" of the group following its defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank every member of the UK armed forces involved in this mission for their professionalism and their valour," Healey commented. "They were among a great many British troops deployed over the festive period. This action, to take out dangerous terrorists who pose a risk to our security, shows how UK forces are ready to step up, throughout the year, ensuring Britain's security within its borders and influential overseas."
In December, the US military carried out what it called a "large-scale strike" on Daesh sites in Syria, after an assault claimed the lives of two US servicemembers and a civilian linguist in the Palmyra area.
The United Nations says IS still maintains roughly 5-7 thousand fighters in Syria and Iraq.